Impact of High Aspartame and High Fructose Diet on Vascular Reactivity, Glucose Metabolism and Liver Structure in Diabetic Rats

BACKGROUND: Diabetes mellitus is a chronic metabolic disorder, affected by fructose, and artificial sweeteners. Aspartame fructose are popularly used, diabetics, as substitutes to glucose. AIM: This study evaluated the effect of high aspartame on vascular reactivity, glucose, hepatic metabolism in diabetic rats. MATERIALS AND METHODS: Forty-eight male rats were divided into six groups: Control, control-diabetic, aspartame, aspartame-diabetic, fructose-diabetic. After 60 days, blood pressure, reactivity norepinephrine, Lipid profile, fasting insulin, homeostasis model assessment insulin resistance (HOMA-IR), leptin, Malondialdehyde (MDA) measured. RESULTS: High alone or with diabetes, decreased increased triglyceride, cholesterol, MDA, Hepatic tissues showed dilated congested vessels, cellular infiltration, Periodic Acid Schiff’s reaction, collagenous fibers. high-density lipoprotein, Low-density HOMA-IR. more fatty glycogen deposition, collagenous-fibers. The condition became worse diabetes-treated CONCLUSION: diet caused deleterious effects atherogenic, oxidative stress, vascular, tissue impairment.